DETAILED NOTES ON METHADONE NURSING IMPLICATIONS

[61] Like several other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with different potency. Dextromethadone, which happens to be significantly less potent as an opioid, is more strong at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone incorporates a lower affinity, w